Elevated serum IgA following vaccination against SARS-CoV-2 in a cohort of high-risk first responders

Elevated serum IgA following vaccination against SARS-CoV-2 in a cohort of high-risk first responders

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Abstract IgA plays an important early neutralizing role Baby Rashguards after SARS-CoV-2 infection.Systemically administered vaccines typically produce an IgM/IgG predominant response.We evaluated the serum anti-spike (anti-S) IgG, anti-nucleocapsid (anti-N) IgG and anti-S IgA response following vaccination against SARS-CoV-2 in a cohort of first-responders.Among the 378 completely vaccinated participants, 98% were positive for anti-S IgG and 96% were positive for anti-S IgA.Nine percent were positive for anti-N IgG suggesting prior exposure to SARS-CoV-2.

No statistically significant difference was seen in IgA response based on prior evidence infection (p = 0.18).Ninety-eight Left Arm of those receiving the Moderna vaccine (98%) were positive for anti-S IgA as compared to 91% of those who received the copyright vaccine (p = 0.0009).The high proportion of participants observed to have a positive anti-S IgA response after vaccination suggests that the vaccines elicit a systemic response characterized by elevated levels of both IgG and IgA.